Analytical Data
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Gene name
MTG1
- Application
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Alternative Names
MTG1; GTPBP7; Mitochondrial ribosome-associated GTPase 1; GTP-binding protein 7; Mitochondrial GTPase 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BT17
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Expression Region
1-300 aa
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AA Sequence
MAKGLKKMQSSLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGLKNVIFTNCVKDENVKQIIPMVTELIGRSHRYHRKENLEYCIMVIGVPNVGKSSLINSLRRQHLRKGKATRVGGEPGITRAVMSKIQVSERPLMFLLDTPGVLAPRIESVETGLKLALCGTVLDHLVGEETMADYLLYTLNKHQRFGYVQHYGLGSACDNVERVLKSVAVKLGKTQKVKVLTGTGNVNVIQPNYPAAARDFLQTFRRGLLGSVMLDLDVLRGHPPAETLP
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Molecular Weight
59.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MTG1, or "Methyltransferase-like Protein 1," has garnered significant interest in the field of molecular biology due to its potential role in various cellular processes, including gene expression regulation, cellular differentiation, and response to stress. Research has revealed that MTG1 is involved in modifying RNA and potentially influencing the methylation patterns of nucleic acids, which are critical for maintaining genomic stability and regulating gene activity. The protein's homology to other methyltransferases suggests it may play a role in epigenetic modifications, affecting how genes are expressed without altering the DNA sequence itself. Recent findings indicate that disruptions in MTG1 function could lead to aberrant cellular behaviors and contribute to the pathogenesis of several diseases, including cancer and neural disorders. Consequently, investigating the structure, function, and regulation of MTG1 is vital for understanding its contributions to health and disease. The exploration of MTG1 also opens up avenues for therapeutic interventions that target its activity, potentially offering new strategies for combating diseases associated with dysfunctional methylation processes. As research continues to elucidate the precise mechanisms by which MTG1 operates within the cell, it remains a key focus for scientists aiming to decipher complex regulatory networks and develop innovative treatments.
