Analytical Data
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Gene name
PSMD11
- Application
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Alternative Names
PSMD11;26S proteasome non-ATPase regulatory subunit 11
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00231
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Expression Region
1-422aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSHMAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDE EAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVR SLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDT KRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAAL TSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCV AQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIE PFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDE PPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
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Molecular Weight
50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSMD11 is a crucial component of the 26S proteasome, which plays a vital role in protein degradation and regulation of cellular processes. The proteasome is essential for maintaining protein homeostasis by selectively degrading ubiquitinated proteins, thus influencing various cellular pathways, including cell cycle regulation, apoptosis, and signal transduction. Dysregulation of the proteasome, and specifically components like PSMD11, has been associated with numerous diseases, including cancer and neurodegenerative disorders. Recent research highlighted the importance of PSMD11 in mediating the proteasomal degradation of key regulatory proteins, which can significantly impact tumor progression and resistance to therapy. Recombining PSMD11 as a protein for functional studies allows researchers to investigate its biochemical properties, interaction dynamics within the proteasome, and its influence on substrate processing. Additionally, understanding the structure-function relationship of PSMD11 could reveal potential therapeutic targets, making it a significant focus in drug discovery efforts aimed at combating proteasome-related pathologies. The development of PSMD11 recombinant proteins thus serves both as a tool for elucidating fundamental biological mechanisms and as a potential biomarker for disease progression and treatment responses.
