Analytical Data
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基因名
MRPS12
- Application
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别名
28S ribosomal protein S12; 28S ribosomal protein S12 mitochondrial; mitochondrial; Mitochondrial ribosomal protein S12; MRP-S12; MRPS12; MT-RPS12; RPMS12; RPS12; RPSM12; RT12_HUMAN; S12mt
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15235
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表达区间
30-138 aa
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氨基酸序列
M ATLNQMHRLG PPKRPPRKLG PTEGRPQLKG VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH TLQEHQIVLV EGGRTQDLPG VKLTVVRGKY DCGHVQKK
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分子量
15.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPS12, a gene encoding the mitochondrial ribosomal protein S12, has gained attention due to its critical role in mitochondrial protein synthesis and overall cellular metabolism. Mitochondria, known as the powerhouse of the cell, are responsible for producing ATP through oxidative phosphorylation, making the integrity of their protein synthesis essential for energy metabolism. Mutations or dysregulation in mitochondrial proteins can lead to a variety of mitochondrial diseases, which are often characterized by symptoms affecting multiple organ systems, particularly those with high energy demands, such as the brain and muscles. Recent studies have revealed that MRPS12 is involved in the assembly of the mitochondrial ribosome and the maintenance of mitochondrial function. This has prompted researchers to investigate the potential implications of MRPS12 in diseases related to mitochondrial dysfunction, including neurodegenerative disorders and metabolic syndromes. Additionally, as mitochondrial health is increasingly linked to aging and age-related diseases, characterizing MRPS12's function offers insights into the mechanisms of mitochondrial dynamics and the development of therapeutic strategies. Understanding the structure and function of MRPS12 could pave the way for developing targeted gene therapies or small molecules aimed at enhancing mitochondrial function, thereby ameliorating the impacts of mitochondrial diseases and promoting healthy aging.












