Analytical Data
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Gene name
MRPL50
- Application
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Alternative Names
MRPL50; 39S ribosomal protein L50; mitochondrial; L50mt; MRP-L50; Mitochondrial large ribosomal subunit protein mL50
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N5N7
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Expression Region
1-158 aa
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AA Sequence
MAARSVSGIT RRVFMWTVSG TPCREFWSRF RKEKEPVVVE TVEEKKEPIL VCPPLRSRAY TPPEDLQSRL ESYVKEVFGS SLPSNWQDIS LEDSRLKFNL LAHLADDLGH VVPNSRLHQM CRVRDVLDFY NVPIQDRSKF DELSASNLPP NLKITWSY
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Molecular Weight
18.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MRPL50 (Mitochondrial Ribosomal Protein L50) is a crucial component of the mitochondrial ribosome, which is essential for protein synthesis within the mitochondria, the cell’s powerhouse. Research into MRPL50 has gained importance due to its potential implications in various mitochondrial diseases and cellular aging processes. Mitochondrial dysfunction is linked to a range of conditions, including neurodegenerative diseases, metabolic syndromes, and certain cancers, all of which highlight the significance of understanding mitochondrial protein synthesis. Investigating the structure and function of MRPL50 can provide insights into the mechanisms of mitochondrial biogenesis and protein assembly, as well as its role in the regulation of apoptosis and oxidative stress responses. Additionally, MRPL50's interactions with mitochondrial mRNAs and its involvement in translational regulation are areas of active research, aimed at uncovering how disruptions in this protein can lead to disease pathology. Studying MRPL50 not only enhances our understanding of mitochondrial function but also opens up potential therapeutic avenues for targeting mitochondrial dysfunction in various diseases. Given the rising prevalence of mitochondrial-related disorders, the research on MRPL50 and its implications in health and disease continues to be a significant focus in molecular biology and biomedicine.
