Analytical Data
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基因名
BAG1
- Application
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别名
BAG1；HAP；BAG family molecular chaperone regulator 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99933
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表达区间
1-345aa
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氨基酸序列
MAQRGGARRP RGDRERLGSR LRALRPGREP RQSEPPAQRG PPPSGRPPAR STASGHDRPT RGAAAGARRP RMKKKTRRRS TRSEELTRSE ELTLSEEATW SEEATQSEEA TQGEEMNRSQ EVTRDEESTR SEEVTREEMA AAGLTVTVTH SNEKHDLHVT SQQGSSEPVV QDLAQVVEEV IGVPQSFQKL IFKGKSLKEM ETPLSALGIQ DGCRVMLIGK KNSPQEEVEL KKLKHLEKSV EKIADQLEEL NKELTGIQQG FLPKDLQAEA LCKLDRRVKA TIEQFMKILE EIDTLILPEN FKDSRLKRKG LVKKVQAFLA ECDTVEQNIC QETERLQSTN FALAE
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分子量
38.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BAG1, a member of the Bcl-2-associated athanogene (BAG) family, plays a significant role in cellular processes such as protein folding, degradation, and apoptosis regulation. The BAG1 protein contains a BAG domain that interacts with heat shock proteins (HSPs), particularly HSP70, to mediate stress responses and enhance protein chaperoning mechanisms. It has been implicated in various physiological processes and diseases, including cancer, neurodegeneration, and cardiac dysfunction. Research has highlighted BAG1's potential as a therapeutic target due to its ability to modulate cell survival and apoptosis pathways. By understanding the molecular mechanisms underlying BAG1 interactions and functions, scientists aim to develop innovative strategies for disease intervention, particularly in conditions where cellular stress and misfolded proteins are prevalent. Thus, the study of BAG1 recombinant protein is crucial for elucidating its role in health and disease, potentially leading to novel therapeutic approaches that leverage its unique properties in regulating cellular homeostasis.
