Analytical Data
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基因名
ABCD4
- Application
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别名
ABCD4；PXMP1L；Lysosomal cobalamin transporter ABCD4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14678
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表达区间
1-606aa
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氨基酸序列
MAVAGPAPGAGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQSTGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWELMRIKVE
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分子量
68.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCD4 is a member of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in cellular processes such as lipid metabolism, detoxification, and the transport of various substrates across membranes. Recent studies have highlighted the significance of ABCD4 in the context of peroxisomal function, particularly its involvement in the transport of fatty acids and the metabolism of very long-chain fatty acids (VLCFAs). Mutations in the ABCD4 gene have been associated with several lipid metabolism disorders, including X-linked adrenoleukodystrophy and Zellweger syndrome, underscoring its importance in human health. The study of recombinant ABCD4 protein has gained momentum as researchers strive to elucidate its structure, function, and mechanism of action. By producing and characterizing this protein in vitro, scientists aim to better understand its transport capabilities and regulatory mechanisms, which could reveal potential therapeutic targets for related diseases. Additionally, the recombinant protein can serve as a valuable tool in drug discovery and the development of therapies aimed at modulating ABCD4 activity. Exploring the biophysical properties and interactions of ABCD4 with its specific substrates could provide insights into the complexities of lipid transport and metabolism, ultimately contributing to advancements in the treatment of metabolic disorders linked to this essential transporter.
