Analytical Data
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基因名
PTPN22
- Application
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别名
PTPN22；Protein-tyrosine-phosphatase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y2R2
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表达区间
1-179aa
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氨基酸序列
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAE KPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYI ATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKEAEKRKSDYIIRTL KVKFNSVSVILAHQTSLQNLFSQITPAHF
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分子量
45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPN22, or protein tyrosine phosphatase non-receptor type 22, is a negative regulator of T cell activation and has emerged as a critical player in autoimmunity and various diseases. Its main function is to negatively regulate signaling pathways that promote T cell activation, thereby maintaining immune tolerance. Dysregulation or mutations in the PTPN22 gene have been strongly associated with autoimmune diseases, such as rheumatoid arthritis, type 1 diabetes, and systemic lupus erythematosus. This has spurred significant interest in understanding the molecular mechanisms of PTPN22's action. The study of PTPN22 recombinant proteins allows researchers to explore its structure-function relationships, investigate its interactions with other signaling molecules, and assess its role in immune cell signaling pathways. Furthermore, recombinant PTPN22 proteins can be utilized in therapeutic applications, including the development of targeted therapies for autoimmune diseases. Insights gained from these studies may not only enhance our knowledge of the immune system but also pave the way for novel therapeutic strategies to modulate immune responses in various pathological conditions.
