Analytical Data
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Gene name
MEN1
- Application
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Alternative Names
MEA 1; MEA1; MEN 1; Men1; MEN1_HUMAN; Menin; Multiple Endocrine Adenomatosis 1; Multiple Endocrine Neoplasia 1; SCG 2; SCG2; Suppressor Candidate Gene 2; Wermer syndrome; ZES; Zollinger Ellison Syndrome
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00255
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Expression Region
1-615aa
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AA Sequence
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK VSDVIWNSLS RSYFKDRAHI QSLFSFITGW SPVGTKLDSS GVAFAVVGAC QALGLRDVHL ALSEDHAWVV FGPNGEQTAE VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ GTQSQGSALQ DPECFAHLLR FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEEPWGEEA REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP RKPPGTVAGT ARGPEGGSTA QVPAPTASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP SDYTLSFLKR QRKGL
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Molecular Weight
67,4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MEN1, or Multiple Endocrine Neoplasia type 1, is a rare hereditary disorder characterized by the development of tumors in multiple endocrine glands, primarily the pituitary, pancreas, and parathyroid glands. The MEN1 gene, which encodes a protein known as menin, plays a crucial role in cell proliferation, apoptosis, and genomic stability. Mutations in the MEN1 gene lead to loss of menin function, resulting in uncontrolled cell growth and tumor formation. Research on MEN1 recombinant protein focuses on understanding the molecular mechanisms by which menin regulates gene expression and cell signaling pathways. The study of menin's structure and function, as well as its interactions with other cellular proteins, has implications for unraveling the pathogenesis of MEN1-related tumors. Furthermore, the recombinant protein can be used to develop targeted therapies or gene-editing strategies to restore menin function in affected patients. This line of research is not only critical for understanding MEN1 but also has broader implications for other cancers where similar mechanisms of tumorigenesis are at play. Advances in this field may lead to novel diagnostic tools, preventive measures, and therapeutic options for individuals at risk of MEN1, ultimately improving patient outcomes and quality of life.
