Analytical Data
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基因名
SLC19A1
- Application
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别名
SLC19A1；FLOT1；RFC1；Reduced folate transporter
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41440
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表达区间
420-591aa
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氨基酸序列
DVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
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分子量
25.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC19A1, also known as the solute carrier family 19 member 1, encodes a high-affinity folate transport protein that plays a crucial role in cellular folate uptake and intracellular folate homeostasis. Given the pivotal role of folates in various biological processes, including DNA synthesis and repair, SLC19A1 has gained attention in biomedical research, particularly concerning its implications in cancer, neurological disorders, and developmental abnormalities. Mutations or polymorphisms in the SLC19A1 gene can lead to altered transport activity, potentially impacting folate availability and influencing disease susceptibility. The recombinant expression of SLC19A1 protein facilitates detailed studies on its transport mechanisms, functional properties, and regulatory networks, enabling researchers to understand how variations in this protein contribute to pathophysiological conditions. Furthermore, studying the recombinant protein provides insights into the development of targeted therapies and the optimization of folate-related treatments. As the understanding of SLC19A1's role in health and disease deepens, it has potential implications for nutritional interventions and pharmacogenomics, making it an important target for ongoing research and therapeutic exploration.
