Analytical Data
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Gene name
PDLIM1
- Application
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Alternative Names
PDLIM1;CLIM1;CLP36;PDZ and LIM domain Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00151
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Expression Region
1-329aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSEFMTTQQ IDLQGPGPWG FRLVGGKDFE QPLAISRVTP GSKAALANLC IGDVITAIDG ENTSNMTHLE AQNRIKGCTD NLTLTVARSE HKVWSPLVTE EGKRHPYKMN LASEPQEVLH IGSAHNRSAM PFTASPASST TARVITNQYN NPAGLYSSEN ISNFNNALES KTAASGVEAN SRPLDHAQPP SSLVIDKESE VYKMLQEKQE LNEPPKQSTS FLVLQEILES EEKGDPNKPS GFRSVKAPVT KVAASIGNAQ KLPMCDKCGT GIVGVFVKLR DRHRHPECYV CTDCGTNLKQ KGHFFVEDQI YCEKHARERV TPPEGYEVVT VFPK
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Molecular Weight
39 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PDLIM1, a member of the PDZ-LIM domain protein family, has garnered significant attention in recent years due to its crucial roles in cellular processes such as cell adhesion, migration, and signal transduction. This protein is characterized by its PDZ and LIM domains, which facilitate interactions with various signaling molecules and cytoskeletal components, thereby influencing cellular architecture and function. Dysregulation of PDLIM1 has been implicated in several pathological conditions, including cancer metastasis and cardiovascular diseases. As a result, understanding its structure and function is pivotal for elucidating its biological roles and potential therapeutic applications. The recombinant expression of PDLIM1 allows for detailed investigations into its biochemical properties and interactions, providing insights into how it modulates cellular processes. By studying PDLIM1 in a controlled environment, researchers aim to decipher its mechanisms of action, contributing to the broader understanding of its involvement in disease and identification of potential drug targets. The ongoing research in this field highlights the importance of PDLIM1 as a subject of study, given its potential implications in developing novel therapeutic strategies.
