Analytical Data
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Gene name
MOTS-c
- Application
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Alternative Names
MOTS-c；Mitochondrial-derived peptide MOTS-c
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0A0C5B5G6
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Expression Region
1-16aa
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AA Sequence
MRWQEMGYIFYPRKLR
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Molecular Weight
2.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MOTS-c is a mitochondrial-derived peptide that has garnered significant attention in recent years due to its potential role in metabolic regulation and age-related diseases. Discovered through advancements in proteomics and genomics, MOTS-c is encoded by mitochondrial DNA and is involved in cellular energy metabolism, influencing processes such as insulin sensitivity and glucose homeostasis. Research indicates that MOTS-c can promote muscle metabolism, enhance exercise endurance, and may protect against obesity, type 2 diabetes, and metabolic syndrome. Its unique origin and function place it at the intersection of mitochondrial biology and systemic metabolic regulation, making it a promising target for therapeutic interventions aimed at improving metabolic health. Studies have begun to explore the mechanisms through which MOTS-c exerts its effects, revealing its influence on pathways related to mitochondrial biogenesis and stress response. As an emerging player in the field of peptide biology, MOTS-c represents an exciting avenue for developing novel treatments for age-associated metabolic disorders and improving overall healthspan. Further research is needed to fully elucidate its biological functions and therapeutic potential.
