Analytical Data
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基因名
GRPR
- Application
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别名
GRPR；Gastrin-releasing peptide receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30550
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表达区间
1-384aa
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氨基酸序列
MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVI ILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASR YLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQA SHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYP HSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNI HVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHS TGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
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分子量
68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Gastrin-releasing peptide receptor (GRPR) is a member of the bombesin receptor family and is primarily known for its role in various physiological processes, including the regulation of gastrin release and modulation of gastric motility. GRPR has garnered significant attention in cancer research, particularly due to its overexpression in several malignancies, including prostate, breast, and non-small cell lung cancers. This overexpression presents GRPR as a promising target for novel diagnostic and therapeutic strategies. In recent years, the development of GRPR-targeted imaging and therapy, utilizing radiolabeled peptides and small molecules, has shown potential in improving tumor visualization and treatment effectiveness. Furthermore, GRPR is implicated in neurogenic inflammation and the central nervous system's regulation, paving the way for research on its role in neurological disorders. Investigating GRPR and its signaling pathways may lead to breakthroughs in understanding tumor biology and enhancing targeted therapies, thereby offering new hope for patients suffering from GRPR-expressing cancers. As a result, GRPR-based research continues to expand, aiming to uncover its full potential in clinical applications and improve patient outcomes.
