Cat: PA2000-617DB

Recombinant Human SLC9A3R2 Protein,His

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Analytical Data

  • Gene name

    SLC9A3R2

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    SLC9A3R2;TDF;Sex-determining region Y Protein

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q15599

  • Expression Region

    1-337aa

  • AA Sequence

    MAAPEPLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL RAGDRLVEVN GVNVEGETHH QVVQRIKAVE GQTRLLVVDQ ETDEELRRRQ LTCTEEMAQR GLPPAHDPWE PKPDWAHTGS HSSEAGKKDV SGPLRELRPR LCHLRKGPQG YGFNLHSDKS RPGQYIRSVD PGSPAARSGL RAQDRLIEVN GQNVEGLRHA EVVASIKARE DEARLLVVDP ETDEHFKRLR VTPTEEHVEG PLPSPVTNGT SPAQLNGGSA CSSRSDLPGS DKDTEDGSAW KQDPFQESGL HLSPTAAEAK EKARAMRVNK RAPQMDWNRK REIFSNF

  • Molecular Weight

    337 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

SLC9A3R2, also known as Solute Carrier Family 9 Member A3 Regulator 2, is a member of the solute carrier family that plays a crucial role in cellular sodium and pH homeostasis. It functions primarily as a regulator of ion transport mechanisms within epithelial tissues. Research into SLC9A3R2 is particularly significant due to its involvement in various physiological processes and potential implications in diseases such as hypertension, heart failure, and certain kidney disorders. The protein's role in regulating Na+/H+ exchange may influence cellular signaling pathways, affecting calcium levels and numerous other intracellular processes. Moreover, alterations in SLC9A3R2 expression or function can be linked to pathological conditions, highlighting its potential as a therapeutic target. The recombinant expression of SLC9A3R2 provides an invaluable tool for studying its structure-function relationships and for developing specific inhibitors or activators that may modulate its activity. By investigating the protein's interactions, regulatory mechanisms, and impact on cellular environments, researchers aim to better understand its contributions to health and disease, paving the way for novel therapeutic strategies that leverage the modulation of this transport system.

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