Analytical Data
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Gene name
FOXM1
- Application
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Alternative Names
FOXM1；FKHL16；HFH11；MPP2；Forkhead box Protein M1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q08050
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Expression Region
222-360aa
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AA Sequence
PSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTIKTELP
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Molecular Weight
43.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOXM1, a member of the forkhead box (FOX) family of transcription factors, plays a crucial role in cell proliferation, differentiation, and survival. It is characteristically overexpressed in various cancers, making it a significant focus for cancer research. The protein is involved in critical cellular processes such as the cell cycle regulation, DNA damage repair, and the modulation of apoptosis, suggesting that its dysregulation can contribute to tumorigenesis. Research on recombinant FOXM1 proteins has gained prominence due to the necessity to understand its functional mechanisms and interactions within various signaling pathways. By producing FOXM1 as a recombinant protein, scientists can investigate its structural properties, post-translational modifications, and interactions with other cellular partners. Such studies not only deepen our understanding of FOXM1's role in cancer biology but also pave the way for potential therapeutic strategies aimed at targeting FOXM1 activity. Additionally, identifying small molecules or peptides that can inhibit FOXM1 may lead to novel cancer treatments, underscoring the importance of elucidating its functionality through recombinant protein studies.
