Analytical Data
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基因名
NEIL2
- Application
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别名
NEIL2;Endonuclease 8-like 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q969S2
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表达区间
1-332aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSHMPEGPLVRKFHHLVSPFVGQQVVKTG GSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQK EVQKEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGD AGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHFGGGGFLA FYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYF SGLGNIIKNEALYRAGIHPLSLGSVLSASRREVLVDHVVEFSTAWLQGKF QGRPQHTQVYQKEQCPAGHQVMKEAFGPEDGLQRLTWWCPQCQPQLSEEP EQCQFS
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分子量
39 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The NEIL2 protein, a member of the NEIL family of DNA glycosylases, plays a crucial role in the base excision repair (BER) pathway, which is essential for maintaining genomic integrity. It is primarily responsible for recognizing and excising damaged bases resulting from oxidative stress, thereby preventing the accumulation of mutations that can lead to various diseases, including cancer. Research has indicated that NEIL2 preferentially targets oxidized bases, such as 8-oxoguanine, and interacts with other repair proteins to facilitate efficient DNA repair processes. Given its importance in genome maintenance, studying NEIL2 has significant implications for understanding the molecular mechanisms behind DNA repair, the role of oxidative damage in aging and disease, and the development of potential therapeutic strategies. Investigating the regulatory mechanisms and structural features of NEIL2 may also provide insights into its functional diversity and interactions with other cellular components involved in DNA repair pathways. Overall, the exploration of NEIL2's function and mechanisms presents a promising avenue for advancing our knowledge of cellular responses to DNA damage and maintaining cellular homeostasis.
