Analytical Data
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Gene name
NEIL2
- Application
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Alternative Names
NEIL2;Endonuclease 8-like 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969S2
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Expression Region
1-332aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSHMPEGPLVRKFHHLVSPFVGQQVVKTG GSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQK EVQKEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGD AGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHFGGGGFLA FYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYF SGLGNIIKNEALYRAGIHPLSLGSVLSASRREVLVDHVVEFSTAWLQGKF QGRPQHTQVYQKEQCPAGHQVMKEAFGPEDGLQRLTWWCPQCQPQLSEEP EQCQFS
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Molecular Weight
39 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The NEIL2 protein, a member of the NEIL family of DNA glycosylases, plays a crucial role in the base excision repair (BER) pathway, which is essential for maintaining genomic integrity. It is primarily responsible for recognizing and excising damaged bases resulting from oxidative stress, thereby preventing the accumulation of mutations that can lead to various diseases, including cancer. Research has indicated that NEIL2 preferentially targets oxidized bases, such as 8-oxoguanine, and interacts with other repair proteins to facilitate efficient DNA repair processes. Given its importance in genome maintenance, studying NEIL2 has significant implications for understanding the molecular mechanisms behind DNA repair, the role of oxidative damage in aging and disease, and the development of potential therapeutic strategies. Investigating the regulatory mechanisms and structural features of NEIL2 may also provide insights into its functional diversity and interactions with other cellular components involved in DNA repair pathways. Overall, the exploration of NEIL2's function and mechanisms presents a promising avenue for advancing our knowledge of cellular responses to DNA damage and maintaining cellular homeostasis.
