Analytical Data
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基因名
LRMP
- Application
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别名
Lrmp; LRMP_HUMAN; Lymphoid restricted membrane protein; Processed lymphoid-restricted membrane protein; Protein Jaw1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12912
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表达区间
1-555aa
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氨基酸序列
MESTPFSGVANQIHTLCERPTYGEVKDGALDVKRQHKCPGPTSGPSPGTNLSGCIRMNDDPSMEENGVERVCPESLLQSREYSSLPLPRHTSSTDGTITSSDPGLEILNMASCDLDRNSLCKKEEDTRSASPTIEAQGTSPAHDNIAFQDSTSKDKTILNLEAKEEPETIEEHKKEHASGDSVVSPLPVTTVKSVNLRQSENTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPLCEDDNQAQEIIKKLEKSIKFLSQCAARVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDDDDCQIKKRSASLNSKPSSLRRVTIASLPRNIGNAGMVAGMENNDRFSRRSSSWRILGSKQSEHRPSLPRFISTYSWADAEEEKCELKTKDDSEPSGEETVERTRKPSLSEKKNNPSKWDVSSVYDTIASWATNLKSSIRKANKALWLSIAFIVLFAALMSFLTGQLFQKSVDAAPTQQEDSWTSLEHILWPFTRLRHNGPPPV
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分子量
62.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRMP, or Lymphocyte-Recombination Mediated Protein, plays a crucial role in the immune system, particularly in the processes of lymphocyte development and antigen receptor gene rearrangement. The significance of LRMP arises from its involvement in the maturation of B and T cells, where it assists in the recombination of immunoglobulin and T-cell receptor genes, a vital step for generating diversity in the immune response. Studies have shown that LRMP is essential for the proper functioning of the recombination activating gene (RAG) complex, which is responsible for initiating the rearrangement of immune receptor genes. Disruptions in LRMP expression can lead to immunological disorders, making it a critical focus for understanding various diseases, including immunodeficiencies and hematological malignancies. Researchers are increasingly investigating the molecular mechanisms underlying LRMP's role, aiming to elucidate its interactions with other proteins and its regulatory functions in lymphocyte biology. By studying LRMP, scientists hope to uncover novel therapeutic strategies to enhance immune responses or rectify immune dysfunctions, reinforcing the importance of this protein in both fundamental immunology and potential clinical applications.
