Analytical Data
-
Gene name
LRMP
- Application
-
Alternative Names
Lrmp; LRMP_HUMAN; Lymphoid restricted membrane protein; Processed lymphoid-restricted membrane protein; Protein Jaw1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q12912
-
Expression Region
1-555aa
-
AA Sequence
MESTPFSGVANQIHTLCERPTYGEVKDGALDVKRQHKCPGPTSGPSPGTNLSGCIRMNDDPSMEENGVERVCPESLLQSREYSSLPLPRHTSSTDGTITSSDPGLEILNMASCDLDRNSLCKKEEDTRSASPTIEAQGTSPAHDNIAFQDSTSKDKTILNLEAKEEPETIEEHKKEHASGDSVVSPLPVTTVKSVNLRQSENTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPLCEDDNQAQEIIKKLEKSIKFLSQCAARVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDDDDCQIKKRSASLNSKPSSLRRVTIASLPRNIGNAGMVAGMENNDRFSRRSSSWRILGSKQSEHRPSLPRFISTYSWADAEEEKCELKTKDDSEPSGEETVERTRKPSLSEKKNNPSKWDVSSVYDTIASWATNLKSSIRKANKALWLSIAFIVLFAALMSFLTGQLFQKSVDAAPTQQEDSWTSLEHILWPFTRLRHNGPPPV
-
Molecular Weight
62.1 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LRMP, or Lymphocyte-Recombination Mediated Protein, plays a crucial role in the immune system, particularly in the processes of lymphocyte development and antigen receptor gene rearrangement. The significance of LRMP arises from its involvement in the maturation of B and T cells, where it assists in the recombination of immunoglobulin and T-cell receptor genes, a vital step for generating diversity in the immune response. Studies have shown that LRMP is essential for the proper functioning of the recombination activating gene (RAG) complex, which is responsible for initiating the rearrangement of immune receptor genes. Disruptions in LRMP expression can lead to immunological disorders, making it a critical focus for understanding various diseases, including immunodeficiencies and hematological malignancies. Researchers are increasingly investigating the molecular mechanisms underlying LRMP's role, aiming to elucidate its interactions with other proteins and its regulatory functions in lymphocyte biology. By studying LRMP, scientists hope to uncover novel therapeutic strategies to enhance immune responses or rectify immune dysfunctions, reinforcing the importance of this protein in both fundamental immunology and potential clinical applications.
