Analytical Data
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基因名
KRTAP5-6
- Application
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别名
KRTAP5-6; KAP5.6; KRTAP5.6Keratin-associated protein 5-6; Keratin-associated protein 5.6; Ultrahigh sulfur keratin-associated protein 5.6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6L8G9
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表达区间
1-129aa
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氨基酸序列
MGCCGCSGGC GSGCGGCGSG CGGCGSSCCV PICCCKPVCC CVPACSCTSC GSCGGSKGCC GSCGGSKGGC GSCGGSKGGC GSCGCSQCSC CKPCYCSSGC GSSCCQSSCC KPCCSQASCC VPICCQCKI
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分子量
11.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRTAP5-6, a member of the keratin-associated protein (KRTAP) family, is known for its role in the structure and function of hair, skin, and other epithelial tissues. These proteins contribute crucially to keratin fiber formation, influencing hair texture, strength, and resilience. Research into KRTAP5-6 has gained interest due to its potential implications in understanding hair disorders, such as alopecia and various hair texture abnormalities. The expression of KRTAP5-6, which is primarily found in hair follicles, is regulated by multiple factors including genetic, hormonal, and environmental influences. Advances in molecular biology techniques, such as recombinant protein expression and CRISPR-Cas9 gene editing, have enabled researchers to explore the functional roles of KRTAP5-6 in greater detail. The insights gained from studying this protein may pave the way for new therapeutic approaches for hair and skin conditions, enhancing our understanding of keratinocyte biology and ultimately contributing to advancements in regenerative medicine and dermatology. The characterization and functional analysis of KRTAP5-6 could reveal its specific interactions with keratins and other structural proteins, shedding light on the mechanical properties of hair and their variations among individuals. Overall, the exploration of KRTAP5-6 not only enriches fundamental knowledge in keratin biology but also holds promise for practical applications in treating hair-related ailments, making it a valuable target for ongoing research in dermatological sciences.
