Analytical Data
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基因名
ADRb3
- Application
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别名
ADRb3；ADRB3R；B3AR；Beta-3 adrenergic receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P13945
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表达区间
1-408aa
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氨基酸序列
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
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分子量
49.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The ADRb3 receptor, a member of the adrenergic receptor family, plays a crucial role in various physiological processes, including lipolysis, thermogenesis, and the modulation of energy expenditure. Its importance has drawn significant attention in the context of metabolic disorders, obesity, and related conditions. Research has shown that ADRb3 is primarily expressed in adipose tissue, where it mediates the effects of catecholamines on fat metabolism. In recent years, the generation and study of recombinant ADRb3 proteins have provided valuable insights into the receptor's structure-function relationships and its signaling mechanisms. By utilizing advanced techniques such as protein engineering and expression in suitable systems, researchers have been able to produce functional ADRb3 variants, allowing for detailed pharmacological characterization and the exploration of potential therapeutic targets. Furthermore, these studies aid in understanding the receptor's role in the pathophysiology of metabolic diseases and may contribute to the development of novel drugs aimed at modulating adrenergic signaling pathways. Overall, the investigation of ADRb3 recombinant proteins represents a promising avenue for uncovering new strategies to tackle obesity and its associated metabolic complications.
