Analytical Data
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基因名
IL12RB1
- Application
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别名
IL23A;SGRF;Interleukin-23 subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42701-3
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表达区间
1-381aa
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氨基酸序列
MEPLVTWVVPLLFLFLLPRQGAACRTSECCFQDPPYPDADSGSASGPRDL RCYRISSDRYECSWQYEGPTAGVSHFLRCCLSSGRCCYFAAGSATRLQFS DQAGVSVLYTVTLWVESWARNQTEKSPEVTLQLYNSVKYEPPLGDIKVSK LAGQLRMEWETPDNQVGAEVQFRHRTPSSPWKLGDCGPQDDDTESCLCPL EMNVAQEFQLRRRRLGSQGSSWSKWSSPVCVPPENPPQPQVRFSVEQLGQ DGRRRLTLKEQPTQLELPEGCQGLAPGTEVTYRLQLHMLSCPCKAKATRT LHLGKMPYLSGAAYNVAVISSNQFGPGLNQTWHIPADTHTDGMISAHCNL RLPDSRDSPASASRVAGITGICHHTRLILYF
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分子量
68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL12RB1, or Interleukin 12 Receptor Subunit Beta 1, is a critical component of the interleukin-12 receptor complex, which plays a significant role in the immune response. This protein is essential for mediating the effects of interleukin-12, a cytokine involved in promoting Th1-type immune responses. Dysregulation of IL12RB1 has been associated with various autoimmune diseases, chronic infections, and cancers, underscoring its importance in maintaining immune system balance. Research into IL12RB1 recombinant protein is vital for understanding its functional mechanisms and role in immune regulation. By studying this protein, scientists aim to explore potential therapeutic intervention strategies, including the use of recombinant proteins in vaccine development or as part of treatments for diseases characterized by immune dysregulation. Furthermore, elucidating the structure and dynamics of IL12RB1 can provide insights into drug design, targeting this pathway to enhance immune responses or ameliorate pathological conditions. Overall, the study of IL12RB1 recombinant protein offers promising avenues for advancing immunotherapy and improving patient outcomes in various immune-related disorders.
