Cat: PA2000-8548

Recombinant Human JRK Protein,His

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Analytical Data

  • Gene name

    JRK

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    JRK; JH8; Jerky protein homolog

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    O75564

  • Expression Region

    1-520aa

  • AA Sequence

    MSTLYDIRAH KAQLLRFFAS SDSNKALEQR RTLHTPKLEH LDRVLYEWFL GKRSEGVPVS GPMLIEKAKD FYEQMQLTEP CVFSGGWLWR FKARHGIKKL DASSEKQSAD HQAAEQFCAF FRSLAAEHGL SAEQVYNADE TGLFWRCLPN PTPEGGAVPG PKQGKDRLTV LMCANATGSH RLKPLAIGKC SGPRAFKGIQ HLPVAYKAQG NAWVDKEIFS DWFHHIFVPS VREHFRTIGL PEDSKAVLLL DSSRAHPQEA ELVSSNVFTI FLPASVASLV QPMEQGIRRD FMRNFINPPV PLQGPHARYN MNDAIFSVAC AWNAVPSHVF RRAWRKLWPS VAFAEGSSSE EELEAECFPV KPHNKSFAHI LELVKEGSSC PGQLRQRQAA SWGVAGREAE GGRPPAATSP AEVVWSSEKT PKADQDGRGD PGEGEEVAWE QAAVAFDAVL RFAERQPCFS AQEVGQLRAL RAVFRSQQQV RRRRGALGAV VKVEALQEGP GGCGATAQSP LPCSSTAGDN

  • Molecular Weight

    61.8 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

JRK (Jumonji domain-containing protein) is a multi-functional protein that plays a crucial role in various biological processes, including gene regulation, DNA repair, and protein folding. Its unique structure, characterized by a Jumonji C (JmjC) domain, allows it to interact with a wide variety of molecular targets. Recent studies have highlighted the significance of JRK in maintaining genomic stability and its potential involvement in oncogenesis, as alterations in its expression or function have been associated with several types of cancer. The reconstitution of JRK protein through recombinant DNA technology has become a focal point of research, as it enables the exploration of its biochemical properties and elucidation of its specific roles within cellular pathways. By producing JRK in a controlled laboratory environment, researchers aim to better understand its mechanism of action and potential therapeutic applications, particularly in cancer treatment and other diseases linked to cellular stress responses. The ongoing research around the characterization and functional analysis of JRK not only enhances our grasp of cellular biology but also opens avenues for novel intervention strategies in oncology and regenerative medicine.

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