Analytical Data
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基因名
ISG20
- Application
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别名
CD25; Estrogen regulated transcript 45 protein; Estrogen-regulated transcript 45 protein; HEM45; Interferon stimulated exonuclease gene 20kDa; Interferon stimulated gene 20 kDa protein; Interferon-stimulated gene 20 kDa protein; Isg20
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96AZ6
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表达区间
1-181aa
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氨基酸序列
MAGSREVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTRVSGVTPQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGYTIYDTSTDRLLWREAKLDHCRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATMELYQISQRIRARRGLPRLAVSD
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分子量
45.65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ISG20 (Interferon-stimulated gene 20) is a prominent antiviral protein that belongs to the exonuclease family and is induced in response to interferon signaling during viral infections. It plays a significant role in the innate immune response by degrading viral RNA, thereby inhibiting viral replication and supporting the host's defense mechanisms. Research on ISG20 has gained momentum due to its potential implications in understanding viral pathogenesis and developing antiviral therapies. Given that several viruses, including HIV, hepatitis C virus, and influenza virus, can evade the immune response, the role of ISG20 in modulating these interactions becomes crucial. Studies have shown that ISG20 can exert antiviral effects not only by degrading viral RNA but also through its involvement in cellular stress responses and apoptosis regulation. These multifaceted functions highlight the protein's importance in the antiviral response, prompting investigations into its mechanisms of action, regulation, and potential as a therapeutic target. Additionally, the exploration of ISG20’s role in various diseases, including cancer and autoimmune disorders, adds another layer to its significance in molecular biology and medicine. Understanding the structure and function of ISG20 could pave the way for innovative strategies to enhance antiviral responses or mitigate associated pathologies, making it a vital subject of ongoing research in immunology and virology.
