Analytical Data
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Gene name
Ccl28
- Application
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Alternative Names
C C motif chemokine ligand 28; C-C motif chemokine 28
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NRJ3
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Expression Region
20-127aa
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AA Sequence
SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVILHVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN SNRAHQGKHE TYGHKTPY
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Molecular Weight
12.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Ccl28, also known as chemokine ligand 28, is a member of the CC chemokine family that plays a crucial role in immune response and inflammation. It is primarily expressed in mucosal tissues, including the gut and salivary glands, where it attracts immune cells to sites of infection and inflammation. Researchers have shown that Ccl28 is involved in recruiting specific subsets of T cells and memory B cells, thereby facilitating the development of an effective immune response in mucosal surfaces. Its importance is highlighted in various disease contexts, such as autoimmune disorders, allergies, and infections, where its expression may be upregulated. The recombinant Ccl28 protein has been produced for research purposes to better understand its biochemical properties and functional mechanisms. This protein enables scientists to explore Ccl28's therapeutic potential, including its application in vaccine development and treatment strategies targeting mucosal immunity. Fresh insights into Ccl28 signaling pathways may pave the way for novel interventions aimed at modulating immune responses, enhancing vaccine efficacy, or developing new therapeutic strategies for diseases that involve aberrant immune activation. The study of Ccl28 and its recombinant forms is crucial for advancing our understanding of mucosal immunology and could lead to significant breakthroughs in the management of various health conditions.
