Analytical Data
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基因名
ITGb4
- Application
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别名
ITGb4；Integrin beta-4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16144
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表达区间
28-710aa
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氨基酸序列
NRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESI VVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLE SPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDK VSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISG NLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVL AGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTN YSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDS PRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLP EDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCG QCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYG EGRYEGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPL SNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIHPGLCE DLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDED DDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSLEHHHHHH
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分子量
78 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ITGb4, an integrin β subunit, plays a crucial role in cell adhesion, migration, and signaling by forming heterodimers with various integrin α subunits. Its involvement in key biological processes makes it a significant target in cancer research, autoimmune disorders, and tissue repair. Studies have shown that ITGb4 is overexpressed in several types of cancers, including breast and lung cancer, where it contributes to tumor progression, metastasis, and the evasion of immune surveillance. Additionally, ITGb4 is essential for maintaining the structural integrity of epithelial tissues, particularly in the formation of hemidesmosomes, which anchor epithelial cells to the basement membrane. Therefore, the exploration of ITGb4 as a therapeutic target has garnered attention, focusing on the development of recombinant proteins and monoclonal antibodies that can inhibit its function or disrupt its interaction with ligands. Recent advancements in recombinant protein technology have facilitated the detailed characterization of ITGb4 interactions and its signaling pathways, paving the way for novel treatment strategies. Understanding the precise mechanisms by which ITGb4 regulates cellular behavior is critical for designing effective interventions in diseases where its dysregulation plays a significant role. Thus, ongoing research on ITGb4 recombinant proteins not only enhances our comprehension of integrin biology but also opens avenues for innovative therapeutic approaches to combat various pathologies associated with this integrin.
