Analytical Data
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Gene name
Ush1c
- Application
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Alternative Names
USH1C;AIE75;Harmonin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y6N9
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Expression Region
1-533aa
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AA Sequence
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF
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Molecular Weight
76.3kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Ush1c (USH1C gene product) is a key protein implicated in Usher syndrome type IC, a genetic disorder leading to hearing loss and vision impairment. Research into Ush1c is critical because it plays a vital role in the development and maintenance of sensory hair cells in the inner ear and photoreceptor cells in the retina. Mutations in the Ush1c gene have been linked to progressive sensorineural hearing loss and retinitis pigmentosa, making the understanding of Ush1c essential for developing potential therapeutic strategies. The study of Ush1c as a recombinant protein allows researchers to investigate its structure, function, and interactions at a molecular level, contributing to the elucidation of its role in cellular processes. By producing Ush1c in a controlled environment, scientists can perform various assays to assess how specific mutations affect protein function and cellular pathways, ultimately aiming to identify targets for gene therapy or pharmacological intervention. The ongoing research efforts focus on understanding the underlying mechanisms of Ush1c in sensory cell function and exploring its potential as a biomarker for Usher syndrome, offering hope for the development of effective treatments for individuals affected by this debilitating condition.
