Analytical Data
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基因名
HKR1
- Application
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别名
ZNF875; HKR1Zinc finger protein 875; Krueppel-related zinc finger protein 1; Protein HKR1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10072
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表达区间
1-659aa
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氨基酸序列
MRVNHTVSTM LPTCMVHRQT MSCSGAGGIT AFVAFRDVAV YFTQEEWRLL SPAQRTLHRE VMLETYNHLV SLEIPSSKPK LIAQLERGEA PWREERKCPL DLCPESKPEI QLSPSCPLIF SSQQALSQHV WLSHLSQLFS SLWAGNPLHL GKHYPEDQKQ QQDPFCFSGK AEWIQEGEDS RLLFGRVSKN GTSKALSSPP EEQQPAQSKE DNTVVDIGSS PERRADLEET DKVLHGLEVS GFGEIKYEEF GPGFIKESNL LSLQKTQTGE TPYMYTEWGD SFGSMSVLIK NPRTHSGGKP YVCRECGRGF TWKSNLITHQ RTHSGEKPYV CKDCGRGFTW KSNLFTHQRT HSGLKPYVCK ECGQSFSLKS NLITHQRAHT GEKPYVCREC GRGFRQHSHL VRHKRTHSGE KPYICRECEQ GFSQKSHLIR HLRTHTGEKP YVCTECGRHF SWKSNLKTHQ RTHSGVKPYV CLECGQCFSL KSNLNKHQRS HTGEKPFVCT ECGRGFTRKS TLSTHQRTHS GEKPFVCAEC GRGFNDKSTL ISHQRTHSGE KPFMCRECGR RFRQKPNLFR HKRAHSGAFV CRECGQGFCA KLTLIKHQRA HAGGKPHVCR ECGQGFSRQS HLIRHQRTHS GEKPYICRKC GRGFSRKSNL IRHQRTHSG
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分子量
75.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HKR1, or Heme Oxygenase-1 Regulator 1, is a protein that has garnered significant attention in medical and biological research due to its potential roles in cellular stress response, inflammatory processes, and apoptosis. Initially discovered as a regulator of heme oxygenase-1 (HO-1), HKR1 has been implicated in various pathological conditions, including cardiovascular diseases, neurodegeneration, and cancer. The expression of HKR1 is often upregulated in response to oxidative stress and various cytokines, suggesting a protective role in maintaining cellular homeostasis. Recent studies have highlighted its involvement in modulating the inflammatory response and promoting cell survival under stress conditions, which makes it a promising target for therapeutic interventions. Researchers are particularly interested in elucidating the molecular mechanisms underlying HKR1 function and its interactions with other signaling pathways. Understanding these pathways could lead to novel strategies for treating diseases characterized by excessive inflammation or impaired cell survival, making HKR1 a critical focus in the field of molecular medicine and therapeutic development. As investigations into HKR1 continue, the potential to harness its regulatory capabilities for clinical applications remains a forefront of scientific inquiry.
