Analytical Data
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Gene name
CD62E
- Application
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Alternative Names
CD62E；ELAM1；E-selectin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P16581
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Expression Region
22-556aa
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AA Sequence
WSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYW IGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKD VGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSG LKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMET MQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFD CEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSP AGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTA LSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWD NEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHG STQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFA CPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIP
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Molecular Weight
60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD62E, also known as E-selectin, is an adhesion molecule predominantly expressed on activated endothelial cells and plays a crucial role in mediating the adhesion of leukocytes to the vascular endothelium during inflammation. The study of CD62E recombinant protein has garnered significant interest due to its potential implications in various pathological conditions, including cardiovascular diseases, autoimmune disorders, and cancer metastasis. Research has shown that CD62E interacts specifically with certain carbohydrate ligands on leukocytes, facilitating their rolling and subsequent adhesion to the endothelium—a key step in the inflammatory response. Understanding the structure and function of CD62E is critical for developing therapeutic strategies aimed at modulating immune responses. The production of recombinant CD62E proteins enables researchers to investigate its biological properties in detail, including its binding affinity to ligands and its role in cell signaling pathways. Furthermore, recombinant CD62E can be utilized in therapeutic applications, such as designing molecules that can block its function to inhibit excessive leukocyte recruitment during inflammatory processes. Overall, the investigation of CD62E recombinant protein provides valuable insights into its function in health and disease, offering potential avenues for intervention in inflammatory and thromboembolic disorders.
