Analytical Data
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基因名
ISM2
- Application
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别名
ISM2；TAIL1；THSD3；Isthmin-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6H9L7
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表达区间
89-571aa
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氨基酸序列
MTPGNATPPRTPEVTPLRLELQKLPGLANTTLSTPNPDTQASASPDPRPLREEEEARLLPRTHLQAELHQHGCWTVTEPAALTPGNATPPRTQEVTPLLLELQKLPELVHATLSTPNPDNQVTIKVVEDPQAEVSIDLLAEPSNPPPQDTLSWLPALWSFLWGDYKGEEKDRAPGEKGEEKEEDEDYPSEDIEGEDQEDKEEDEEEQALWFNGTTDNWDQGWLAPGDWVFKDSVSYDYEPQKEWSPWSPCSGNCSTGKQQRTRPCGYGCTATETRTCDLPSCPGTEDKDTLGLPSEEWKLLARNATDMHDQDVDSCEKWLNCKSDFLIKYLSQMLRDLPSCPCAYPLEAMDSPVSLQDEHQGRSFRWRDASGPRERLDIYQPTARFCLRSMLSGESSTLAAQHCCYDEDSRLLTRGKGAGMPNLISTDFSPKLHFKFDTTPWILCKGDWSRLHAVLPPNNGRACTDNPLEEEYLAQLQEAKEY
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分子量
61.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ISM2 (Inosine monophosphate dehydrogenase 2) is a member of the IMPDH family, which plays a crucial role in the de novo synthesis of purine nucleotides. Research on ISM2 has gained prominence due to its involvement in various physiological processes and potential implications in diseases such as cancer and autoimmune disorders. This enzyme catalyzes the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP), a key step in purine metabolism, thereby influencing cellular proliferation and differentiation. Recent studies have highlighted that dysregulation of ISM2 can lead to altered cellular nucleotide pools, which are associated with enhanced tumor growth and chemoresistance. Furthermore, ISM2 is implicated in the immune response, as its activity affects lymphocyte activation and proliferation. Understanding the structural and functional properties of ISM2 through the study of its recombinant protein is essential for elucidating its mechanisms of action. The generation of recombinant ISM2 allows for detailed biochemical analyses and provides a platform for drug discovery aimed at modulating its activity. Consequently, the characterization of ISM2 as a therapeutic target has significant implications for developing novel treatments for malignancies and immune-related diseases. As research progresses, exploring the effects of ISM2 inhibition or modulation may reveal new therapeutic strategies, underscoring the importance of this enzyme in both health and disease.
