Analytical Data
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Gene name
GPR92
- Application
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Alternative Names
LPAR5; GPR92; GPR93; Lysophosphatidic acid receptor 5; LPA receptor 5; LPA-5; G-protein coupled receptor 92; G-protein coupled receptor 93
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H1C0
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Expression Region
1-372aa
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AA Sequence
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCVFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
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Molecular Weight
66.66 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR92, also known as G-protein coupled receptor 92, belongs to the family of G-protein coupled receptors (GPCRs), which play critical roles in various physiological processes by mediating cellular responses to extracellular signals. Originally identified as a receptor for lysophosphatidic acid (LPA), GPR92 is expressed in various tissues, suggesting its involvement in diverse biological functions, including cell growth, migration, and inflammation. Research on GPR92 is particularly significant due to its potential implications in health and disease, such as its roles in cancer progression and cardiovascular disorders. Given the complexity of GPCR signaling pathways, the study of GPR92 through the production of recombinant proteins is essential for elucidating its structure, function, and signaling mechanisms. Such studies often involve the expression of GPR92 in heterologous systems to facilitate functional assays, pharmacological characterization, and structure-function analyses. Advances in recombinant DNA technology have enabled the generation of stable GPR92 proteins that can be used in high-throughput screening for novel ligands and therapeutic agents. Understanding GPR92 at the molecular level can pave the way for the development of targeted therapies aimed at modulating its activity for therapeutic benefits, making it a vital target for ongoing research in pharmacology and drug discovery.
