Analytical Data
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Gene name
GPR89
- Application
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Alternative Names
GPR89A; GPHRA; GPR89; SH120; CGI-13; UNQ192/PRO218; Golgi pH regulator A; Protein GPR89A; Putative MAPK-activating protein PM01; Putative NF-kappa-B-activating protein 90
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
B7ZAQ6
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Expression Region
1-455aa
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AA Sequence
MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEIRQYVVQVIFSVTFAFSCTMFELIIFEILGVLNSSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNIRLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKGEVHNKPSGFWGMIKSVTTSASGSENLTLIQQEVDALEELSRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGKTDPVTRGIEITVNYLGIQFDVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIMGMYFVSSVLLIRMSMPLEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHKQAPEKQMAP
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Molecular Weight
52.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR89, a member of the G protein-coupled receptor (GPCR) family, has garnered attention due to its potential role in various physiological processes and diseases. Initially identified as an orphan receptor, studies have suggested that GPR89 may be involved in cellular signaling pathways that regulate immune responses, metabolism, and cell proliferation. Its expression has been noted in various tissues, implying a potential role in tissue-specific functions. Recent research has focused on the characterization of GPR89’s structure and function, as understanding its binding mechanisms and cellular interactions could unveil new therapeutic targets for conditions such as obesity, cancer, and autoimmune diseases. The reconstitution of GPR89 in various experimental systems has enabled scientists to delve into its signaling capabilities and physiological implications. As a result, the investigation of GPR89 recombinant proteins has emerged as a critical avenue to elucidate the receptor's biological functions, contributing to the growing body of knowledge regarding GPCRs and their involvement in health and disease. This research not only enhances our understanding of receptor biology but also holds promise for the development of novel therapeutic strategies targeting GPR89-related pathways.
