Analytical Data
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Gene name
GPR151
- Application
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Alternative Names
GPR151; GALR4; GALRL; PGR7; G-protein coupled receptor 151; G-protein coupled receptor PGR7; GPCR-2037; Galanin receptor 4; Galanin-receptor-like protein; GalRL
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TDV0
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Expression Region
1-419aa
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AA Sequence
MLAAAFADSNSSSMNVSFAHLHFAGGYLPSDSQDWRTIIPALLVAVCLVGFVGNLCVIGILLHNAWKGKPSMIHSLILNLSLADLSLLLFSAPIRATAYSKSVWDLGWFVCKSSDWFIHTCMAAKSLTIVVVAKVCFMYASDPAKQVSIHNYTIWSVLVAIWTVASLLPLPEWFFSTIRHHEGVEMCLVDVPAVAEEFMSMFGKLYPLLAFGLPLFFASFYFWRAYDQCKKRGTKTQNLRNQIRSKQVTVMLLSIAIISALLWLPEWVAWLWVWHLKAAGPAPPQGFIALSQVLMFSISSANPLIFLVMSEEFREGLKGVWKWMITKKPPTVSESQETPAGNSEGLPDKVPSPESPASIPEKEKPSSPSSGKGKTEKAEIPILPDVEQFWHERDTVPSVQDNDPIPWEHEDQETGEGVK
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Molecular Weight
73 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR151, also known as an orphan G protein-coupled receptor, has garnered significant interest in recent years due to its potential roles in various physiological and pathological processes. It is primarily expressed in the nervous system, suggesting its involvement in neuronal signaling pathways and potentially in neurodevelopmental disorders. Research has indicated that GPR151 might play a role in the modulation of pain perception, as well as in the regulation of mood and anxiety. Despite its importance, the precise biological functions and molecular mechanisms of GPR151 remain largely unexplored. More specifically, the lack of a known endogenous ligand has hindered a comprehensive understanding of its signaling pathways. As a result, the production and characterization of GPR151 recombinant proteins have become critical to elucidate its functional roles. These studies can help identify potential ligands and downstream signaling cascades, thereby offering insights into its involvement in diseases such as depression, anxiety disorders, and chronic pain conditions. By utilizing recombinant protein technology, researchers aim to develop tools for high-throughput screening of GPR151 ligands, which could eventually lead to the discovery of novel therapeutic targets. Overall, the research on GPR151 recombinant proteins holds promise for advancing our understanding of receptor biology and its implications in health and disease.
