Analytical Data
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基因名
GPR146
- Application
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别名
GPR146; PGR8; Probable G-protein coupled receptor 146; G-protein coupled receptor PGR8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96CH1
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表达区间
1-333aa
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氨基酸序列
MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMTMPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSFSSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA
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分子量
39.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR146, a member of the G protein-coupled receptor (GPCR) family, has emerged as an essential target for research due to its potential implications in various physiological and pathological processes. Despite its identification, the precise biological functions and signaling mechanisms of GPR146 remain largely unexplored. Recent studies suggest that GPR146 may play a role in regulating immune responses, neuronal signaling, and metabolic processes, indicating its importance in maintaining homeostasis. Furthermore, the receptor has been implicated in several diseases, including cancer and metabolic disorders, making it a promising candidate for therapeutic intervention. The generation of recombinant GPR146 protein is crucial for understanding its structure-function relationship, investigating ligand binding, and elucidating its signaling pathways. By characterizing the recombinant protein, researchers aim to uncover the receptor's pharmacological properties and its potential as a drug target. This research could pave the way for the development of novel therapeutic agents that modulate GPR146 activity, thereby offering new strategies for treating diseases associated with receptor dysfunction. As the field of GPCR research continues to advance, GPR146 stands out as a vital subject of investigation, with the potential to contribute significantly to our understanding of GPCR biology and its applications in medicine.
