Analytical Data
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Gene name
GPR146
- Application
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Alternative Names
GPR146; PGR8; Probable G-protein coupled receptor 146; G-protein coupled receptor PGR8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96CH1
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Expression Region
1-333aa
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AA Sequence
MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMTMPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSFSSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA
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Molecular Weight
39.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR146, a member of the G protein-coupled receptor (GPCR) family, has emerged as an essential target for research due to its potential implications in various physiological and pathological processes. Despite its identification, the precise biological functions and signaling mechanisms of GPR146 remain largely unexplored. Recent studies suggest that GPR146 may play a role in regulating immune responses, neuronal signaling, and metabolic processes, indicating its importance in maintaining homeostasis. Furthermore, the receptor has been implicated in several diseases, including cancer and metabolic disorders, making it a promising candidate for therapeutic intervention. The generation of recombinant GPR146 protein is crucial for understanding its structure-function relationship, investigating ligand binding, and elucidating its signaling pathways. By characterizing the recombinant protein, researchers aim to uncover the receptor's pharmacological properties and its potential as a drug target. This research could pave the way for the development of novel therapeutic agents that modulate GPR146 activity, thereby offering new strategies for treating diseases associated with receptor dysfunction. As the field of GPCR research continues to advance, GPR146 stands out as a vital subject of investigation, with the potential to contribute significantly to our understanding of GPCR biology and its applications in medicine.
