Analytical Data
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Gene name
GPR142
- Application
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Alternative Names
GPR142; PGR2; Probable G-protein coupled receptor 142; G-protein coupled receptor PGR2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z601
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Expression Region
1-462aa
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AA Sequence
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
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Molecular Weight
77.77 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GPR142, a member of the G protein-coupled receptor (GPCR) family, has garnered significant interest in the field of neurobiology and pharmacology due to its potential role in regulating metabolic processes and affecting neuropsychiatric conditions. Research has shown that GPR142 is primarily expressed in the central nervous system and is implicated in the modulation of neurotransmitter release, suggesting its involvement in mood regulation and appetite control. Given the increasing prevalence of metabolic disorders and mental health issues worldwide, understanding the functional mechanisms of GPR142 could provide insights into novel therapeutic targets. Additionally, the development of GPR142 recombinant proteins facilitates the investigation of its structure-function relationships and interaction with ligands, paving the way for drug discovery and potential clinical applications. Current studies focus on characterizing the signaling pathways associated with GPR142 and screening for selective agonists or antagonists, which could lead to innovative treatments for conditions such as obesity, depression, and anxiety disorders. Overall, the research on GPR142 is at a promising juncture, with the potential to unveil new biological pathways and therapeutic strategies to address unmet medical needs.
