Analytical Data
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基因名
Plaur
- Application
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别名
Plaur；MO3；UPAR；Urokinase plasminogen activator surface receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q03405
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表达区间
1-335aa
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氨基酸序列
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
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分子量
36.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Plaur, or Plasminogen Activator, Urokinase Receptor, is a crucial protein involved in the regulation of extracellular matrix remodeling and cell migration through its role in the plasminogen activation system. It binds to urokinase-type plasminogen activator (uPA), facilitating the conversion of plasminogen to plasmin, an essential enzyme for the degradation of fibrin and other components of the extracellular matrix. This function is particularly significant in physiological processes such as wound healing, tissue repair, and embryogenesis. However, aberrant expression or activity of Plaur has been implicated in various pathological conditions, including cancer metastasis, acute and chronic inflammatory diseases, and cardiovascular disorders. Consequently, the study of recombinant Plaur protein has gained significant attention as researchers aim to elucidate its molecular mechanisms, potential therapeutic targets, and broader implications in health and disease. By producing recombinant Plaur, scientists can investigate its structural properties, binding interactions, and functional roles in various biological contexts. Moreover, understanding its interactions with other proteins and pathways may lead to novel interventions for diseases characterized by dysregulated extracellular matrix dynamics. The ongoing research in this field holds the promise of providing insights into better diagnostic and therapeutic strategies that target this multifaceted protein.
