Analytical Data
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Gene name
Syt12
- Application
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Alternative Names
(Synaptotagmin XII)(SytXII)(Synaptotagmin-related gene 1 protein)(Srg1)
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Species
Rat
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P97610
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Expression Region
1-421aa
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Molecular Weight
50.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Syt12, or Synaptotagmin 12, is a member of the synaptotagmin family, which is primarily involved in synaptic transmission and calcium signaling in neurons. Research on Syt12 has gained attention due to its unique role in regulating neurotransmitter release and synaptic plasticity. Unlike other synaptotagmins that primarily interact with the presynaptic membrane, Syt12 is thought to participate in intracellular calcium sensing and may play a role in the modulation of synaptic dynamics in various neuronal pathways. Studies have indicated that alterations in Syt12 expression or function may be linked to neurological disorders, making it a potential target for understanding synaptic dysfunction in conditions such as autism, schizophrenia, and other neurodegenerative diseases. The generation of recombinant Syt12 protein allows for detailed biochemical and biophysical analyses, enabling researchers to investigate its structure-function relationships and interactions with other synaptic proteins. Furthermore, understanding Syt12's mechanism of action could lead to new therapeutic strategies aimed at restoring normal synaptic function in pathological states. As such, ongoing research into Syt12 not only enriches our knowledge of synaptic biology but also paves the way for potential clinical applications in the treatment of synaptic dysfunction-related disorders.
