Analytical Data
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Gene name
ENG
- Application
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Alternative Names
ENG；END；Endoglin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P17813
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Expression Region
1-658aa
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AA Sequence
MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA
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Molecular Weight
70.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ENG (Endoglin) is a key glycoprotein that plays a significant role in the regulation of angiogenesis, vascular development, and endothelial cell function. Research on ENG has gained considerable attention due to its implication in various pathological conditions, including preeclampsia, pulmonary arterial hypertension, and certain cancers. ENG is a coreceptor for transforming growth factor-beta (TGF-β) signaling, influencing cellular responses that are crucial for vascular homeostasis. Recent studies have highlighted the importance of ENG in modulating endothelial cell proliferation and migration, suggesting its potential as a therapeutic target in vascular diseases. Additionally, the exploration of ENG as a biomarker for diseases has prompted further investigation into its structural properties and functional mechanisms. The reconstitution of ENG in recombinant protein form has facilitated diverse experimental approaches, allowing researchers to decode its intricate interactions with other signaling pathways. This endeavor not only advances our understanding of vascular biology but also opens new avenues for the development of targeted therapies aimed at mitigating diseases associated with endothelial dysfunction. Overall, the study of ENG and its recombinant forms is pivotal in uncovering novel insights into angiogenesis and provides a promising foundation for innovative treatment strategies in vascular-related disorders.
