Analytical Data
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基因名
ETRA
- Application
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别名
ETRA；ETA；ETRA；Endothelin-1 receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P25101
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表达区间
1-427aa
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氨基酸序列
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVT THQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNAT LLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDH NDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPL VTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEF YQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLM DYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPM NGTSIQWKNHDQNNHNTDRSSHKDSMN
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分子量
75 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ETRA (Estrogen Receptor beta) is a nuclear receptor that plays a critical role in mediating the effects of estrogens on various physiological processes, including development, reproduction, and metabolism. Recent studies have highlighted its significance in cancer biology, particularly in breast and prostate cancers, where ETRA can act as a tumor suppressor or promoter depending on the cellular context. The complexity of ETRA's role in these processes has spurred research into the design and development of recombinant ETRA proteins to elucidate its functions at the molecular level. By producing ETRA as a recombinant protein, researchers aim to study its structure, interactions with specific ligands, and downstream signaling pathways, thereby enhancing our understanding of its biological significance. The generation of recombinant ETRA also facilitates the exploration of its therapeutic potential, as modulation of its activity may offer novel strategies for cancer treatment and hormone-related disorders. Furthermore, the recombinant protein can be used as a tool in drug screening assays, helping to identify compounds that specifically target ETRA's signaling pathway. Overall, the study of recombinant ETRA proteins represents a promising avenue for advancing our knowledge of estrogen signaling and its implications in health and disease.
