Analytical Data
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Gene name
GJA5
- Application
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Alternative Names
(Connexin-40)(Cx40)
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Species
Human
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Source
E. coli
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P36382
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Expression Region
227-358aa
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Molecular Weight
21.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GJA5, or Gap Junction Protein Alpha 5, is a member of the connexin family that plays a critical role in cell communication by forming gap junctions, which allow for the passage of ions and small molecules between adjacent cells. Research on GJA5 has gained attention due to its significance in cardiovascular development and function, particularly in the context of heart rhythm regulation and the pathophysiology of various cardiac diseases, including atrial fibrillation and congenital heart defects. Mutations in the GJA5 gene have been linked to arrhythmogenic disorders, emphasizing the importance of understanding its molecular mechanisms and interactions. Recombinant GJA5 protein studies enable researchers to investigate the structure-function relationship of connexins, identify potential drug targets, and explore therapeutic strategies for cardiac conditions. These studies utilize techniques such as protein expression systems and electrophysiological assays to assess the functional properties of GJA5, contributing to a deeper understanding of its role in cellular communication and its implications for heart health. As such, GJA5 recombinant protein research is pivotal in unraveling the complexities of cardiac signaling and developing innovative approaches to counteract heart-related diseases.
