Analytical Data
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基因名
CSF2RA
- Application
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别名
CSF2RA；CSF2R；CSF2RY;Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P15509
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表达区间
20-320aa
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氨基酸序列
ADPLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKK NRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGR EGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCP YYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIE RFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGT ENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFG SDDGHHHHHH
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分子量
36 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSF2RA (Colony Stimulating Factor 2 Receptor Alpha) is a critical receptor that modulates the immune response by binding to the granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine involved in hematopoiesis and immune regulation. Research into CSF2RA and its recombinant proteins has gained significant attention due to their potential therapeutic applications in treating various diseases, including autoimmune disorders, inflammatory diseases, and certain cancers. The role of GM-CSF in promoting the differentiation and activation of myeloid cells highlights the importance of CSF2RA in immune responses and tissue homeostasis. Recombinant CSF2RA proteins are being studied for their ability to enhance immune responses, particularly in immunotherapy settings, where they may facilitate the anti-tumor activity of immune cells. Moreover, understanding the structure-function relationships of CSF2RA is crucial for developing potent inhibitors or agonists that could serve as therapeutic agents. Overall, the exploration of CSF2RA recombinant proteins offers promising avenues for improving immune-related therapies, with the potential to provide novel strategies for managing a variety of immune-mediated conditions.
