Analytical Data
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基因名
CCND2
- Application
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别名
CCND2；G1/S-specific cyclin-D2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30279
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表达区间
1-289aa
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氨基酸序列
MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL
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分子量
80.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cyclin D2 (CCND2) is a crucial regulatory protein that plays a significant role in cell cycle progression, particularly in the transition from the G1 phase to the S phase. As part of the cyclin family, CCND2 pairs with cyclin-dependent kinases (CDKs) to drive the progression of cells through various phases of the cell cycle. Abnormal expression or mutations in CCND2 have been implicated in several malignancies, making it a target of interest in cancer research. Studies have shown that CCND2 contributes not only to cell proliferation but also to the regulation of apoptosis and differentiation processes. Its overexpression is frequently observed in various cancers, including breast, prostate, and multiple myeloma. Consequently, understanding the structure and function of CCND2, especially through the study of recombinant protein, can provide insights into its mechanistic role in oncogenesis and may reveal potential therapeutic targets for cancer treatment. Research involving the recombinant expression of CCND2 allows scientists to explore its biochemical properties, interactions with CDKs, and its influence on downstream signaling pathways. This knowledge is critical for developing targeted interventions that could inhibit its oncogenic effects, ultimately contributing to improved strategies for cancer therapy.
