Analytical Data
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Gene name
CCNB2
- Application
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Alternative Names
CCNB2；G2/mitotic-specific cyclin-B2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95067
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Expression Region
1-398aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMALLRR PTVSSDLENI DTGVNSKVKS HVTIRRTVLE EIGNRVTTRA AQVAKKAQNT KVPVQPTKTT NVNKQLKPTA SVKPVQMEKL APKGPSPTPE DVSMKEENLC QAFSDALLCK IEDIDNEDWE NPQLCSDYVK DIYQYLRQLE VLQSINPHFL DGRDINGRMR AILVDWLVQV HSKFRLLQET LYMCVGIMDR FLQVQPVSRK KLQLVGITAL LLASKYEEMF SPNIEDFVYI TDNAYTSSQI REMETLILKE LKFELGRPLP LHFLRRASKA GEVDVEQHTL AKYLMELTLI DYDMVHYHPS KVAAAASCLS QKVLGQGKWN LKQQYYTGYT ENEVLEVMQH MAKNVVKVNE NLTKFIAIKN KYASSKLLKI SMIPQLNSKA VKDLASPLIG RS
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Molecular Weight
48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCNB2, or Cyclin B2, is a key regulatory protein involved in the cell cycle, specifically in the transition from the G2 phase to mitosis. Its expression is tightly controlled and is critical for proper cell division and function. Research has indicated that CCNB2 plays a significant role in tumorigenesis, particularly in various cancers where its expression levels are often aberrantly regulated. Understanding the structure and function of CCNB2 through recombinant protein studies is essential for elucidating its role in cell cycle regulation and cancer progression. The recombinant production of CCNB2 enables researchers to explore its biochemical properties, interactions with cyclin-dependent kinases (CDKs), and other cell cycle regulators. Additionally, it provides a valuable tool for drug development, as targeting the CCNB2-CDK complex might lead to novel therapeutic interventions in cancer treatment. Given the clinical implications of aberrant CCNB2 expression, ongoing studies focus on the detailed characterization of its functional mechanisms and potential as a biomarker for cancer diagnostics and prognostics. The insights gained from CCNB2 recombinant protein research not only enhance our understanding of cell cycle dynamics but also pave the way for innovative approaches in cancer therapy.
