Analytical Data
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Gene name
JPH2
- Application
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Alternative Names
JP2; Junctophilin type 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BR39
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Expression Region
Arg5~Ser301
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Molecular Weight
42kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
JPH2, or Junctophilin-2, is a critical protein involved in the formation of junctional complexes between the plasma membrane and the endoplasmic reticulum in cardiac cells. These junctions play a vital role in calcium signaling, which is essential for cardiac contractility and overall heart function. Abnormalities in JPH2 expression or function have been linked to various cardiovascular diseases, such as heart failure and arrhythmias. Research has increasingly focused on understanding the molecular mechanisms underlying JPH2's role in excitable tissues and its potential as a therapeutic target. Recombinant JPH2 protein has emerged as a valuable tool for studying its structure-function relationships and interactions with other proteins involved in calcium handling. By producing and characterizing JPH2 in a controlled environment, researchers aim to elucidate its role in cardiac physiology and pathology, providing insights into new strategies for treating heart diseases. This research not only enhances our understanding of cardiac mechanics but also opens avenues for the development of innovative therapies that could improve heart health and patient outcomes.
