Analytical Data
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Gene name
CASQ
- Application
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Alternative Names
PDIB1; CASQ1; Calsequestrin 1,Fast-Twitch,Skeletal Muscle; Calmitine; Calsequestrin, skeletal muscle isoform
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O09165
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Expression Region
Glu35~Glu249
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Molecular Weight
28.4kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CASQ (Calsequestrin) is a calcium-binding protein predominantly found in the sarcoplasmic reticulum of muscle cells, playing a critical role in calcium storage and release during muscle contraction. Research into recombinant CASQ proteins has garnered significant attention due to their potential applications in understanding muscle physiology and pathology. CASQ is essential for maintaining calcium homeostasis within the sarcoplasmic reticulum, and its dysfunction is linked to various muscular disorders, including myopathies and heart diseases. The recombinant expression of CASQ allows scientists to study its structural and functional properties in detail, providing insights into its role in calcium signaling and muscle contraction mechanisms. By producing CASQ in heterologous systems, researchers can investigate its interaction with other proteins, its post-translational modifications, and its regulatory functions in muscle cells. These studies contribute to a better understanding of the molecular basis of muscle diseases, offering potential avenues for the development of therapeutic strategies aimed at restoring normal calcium handling in affected tissues. Moreover, the ability to produce CASQ as a recombinant protein paves the way for the development of novel biomaterials and biotechnological applications, where precise control of calcium ions is crucial for various bioengineering processes. Overall, researching recombinant CASQ proteins not only deepens our knowledge of muscle biology but also opens doors for innovative approaches in treating muscle-related conditions.
