Analytical Data
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Gene name
EIF3H
- Application
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Alternative Names
eIF-3-gamma; eIF3 gamma; eIF3 p40; eIF3 p40 subunit; eIF3h; EIF3H_HUMAN; EIF3S3; Eukaryotic translation initiation factor 3 subunit 3
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P07911
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Expression Region
1-352aa
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AA Sequence
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
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Molecular Weight
40.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
PIK3Cd (phosphoinositide 3-kinase, catalytic subunit delta) is a critical member of the class I PI3K family, playing a pivotal role in various cellular processes, including growth, proliferation, and survival. This enzyme is predominantly expressed in immune cells, where it regulates signaling pathways essential for adaptive immunity and inflammation. Research has shown that aberrant PIK3Cd activity is linked to several immune disorders, including autoimmune diseases and cancers, emphasizing its potential as a therapeutic target. The functional characterization of PIK3Cd through recombinant protein studies allows for a deeper understanding of its enzymatic mechanisms and interactions with other signaling molecules. This knowledge is crucial for developing specific inhibitors that can modulate its activity, providing novel treatment strategies for diseases associated with PIK3Cd dysregulation. The exploration of PIK3Cd recombinant proteins not only enhances our understanding of its biological roles but also aids in the identification of biomarkers for disease prognosis and therapeutic response. Thus, continued research on PIK3Cd is vital for unlocking novel interventions in immunology and oncology.
