Analytical Data
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Gene name
GDDR
- Application
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Alternative Names
BLOT; Blottin; BRICD1B; BRICHOS domain containing 1B; Down regulated in gastric cancer GDDR; Down-regulated in gastric cancer; Gastrokine-2; GDDR; Gkn2; GKN2_HUMAN
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86XP6
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Expression Region
1-184aa
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AA Sequence
MKILVAFLVVLTIFGIQSHGYEVFNIISPSNNGGNVQETVTIDNEKNTAIINIHAGSCSSTTIFDYKHGYIASRVLSRRACFILKMDHQNIPPLNNLQWYIYEKQALDNMFSSKYTWVKYNPLESLIKDVDWFLLGSPIEKLCKHIPLYKGEVVENTHNVGAGGCAKAGLLGILGISICADIHV
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Molecular Weight
46.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GDDR (G-quadruplex DNA-binding domain) proteins represent a fascinating area of research due to their unique ability to interact with G-quadruplex structures found in nucleic acids. These specialized DNA conformations, characterized by stacked guanine tetrads, are implicated in various biological processes, including gene regulation, telomere maintenance, and genome stability. Recent studies have unveiled that GDDR proteins play crucial roles in cellular mechanisms, influencing transcriptional regulation and participating in the DNA damage response. Dysregulation of these interactions is associated with several diseases, particularly cancer, where G-quadruplexes can affect the expression of oncogenes and tumor suppressor genes. The growing interest in GDDR proteins stems from the potential to exploit their binding properties for therapeutic applications. Small molecules that stabilize G-quadruplexes or modulate the activity of GDDR proteins are being investigated for their ability to selectively target cancer cells while sparing normal tissues. This research not only enhances our understanding of molecular biology but also opens avenues for innovative drug design, providing a promising strategy in the fight against cancer and other G-quadruplex-related disorders.
