Analytical Data
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Gene name
GDAP1L1
- Application
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96MZ0
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Expression Region
1-367aa
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AA Sequence
MATPNNLTPT NCSWWPISAL ESDAAKPAEA PDAPEAASPA HWPRESLVLY HWTQSFSSQK VRLVIAEKGL VCEERDVSLP QSEHKEPWFM RLNLGEEVPV IIHRDNIISD YDQIIDYVER TFTGEHVVAL MPEVGSLQHA RVLQYRELLD ALPMDAYTHG CILHPELTTD SMIPKYATAE IRRHLANATT DLMKLDHEEE PQLSEPYLSK QKKLMAKILE HDDVSYLKKI LGELAMVLDQ IEAELEKRKL ENEGQKCELW LCGCAFTLAD VLLGATLHRL KFLGLSKKYW EDGSRPNLQS FFERVQRRFA FRKVLGDIHT TLLSAVIPNA FRLVKRKPPS FFGASFLMGS LGGMGYFAYW YLKKKYI
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Molecular Weight
68.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GDAP1L1 (Ganglioside-induced differentiation-associated protein 1-like 1) is a member of the GDAP gene family, which is implicated in the differentiation and maintenance of neural cells, particularly in the context of neurological disorders. The protein is believed to play a significant role in mitochondrial dynamics and cell stress responses, suggesting its potential involvement in neurodegenerative diseases and metabolic disorders. Recent studies have highlighted that mutations in GDAP1L1 are linked to various hereditary neuropathies, pointing to its critical function in peripheral nervous system development. The exploration of GDAP1L1 as a recombinant protein is essential for understanding its biological functions at the molecular level, creating opportunities for therapeutic interventions. Investigating GDAP1L1 through recombinant protein expression can illuminate its interactions with other cellular components, elucidate its role in mitochondrial function, and provide insights into the pathways affected by its dysregulation. Furthermore, utilizing this protein as a tool for drug screening or gene therapy may open new avenues for treating conditions associated with GDAP1L1 dysfunction. Thus, the study of GDAP1L1's recombinant protein is of considerable interest within the fields of molecular biology, genetics, and therapeutic development, aiming to bridge the gap between basic research and clinical applications in neurology.
