Analytical Data
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Gene name
GJA9
- Application
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Alternative Names
GJA9; GJA10; Gap junction alpha-9 protein; Connexin-58; Cx58; Connexin-59; Cx59; Gap junction alpha-10 protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P57773
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Expression Region
1-515aa
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AA Sequence
MGDWNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPGCRNVCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRVLEEERQRMKAQLRVELEEVEFEMPRDRRRLEQELCQLEKRKLNKAPLRGTLLCTYVIHIFTRSVVEVGFMIGQYLLYGFHLEPLFKCHGHPCPNIIDCFVSRPTEKTIFLLFMQSIATISLFLNILEIFHLGFKKIKRGLWGKYKLKKEHNEFHANKAKQNVAKYQSTSANSLKRLPSAPDYNLLVEKQTHTAVYPSLNSSSVFQPNPDNHSVNDEKCILDEQETVLSNEISTLSTSCSHFQHISSNNNKDTHKIFGKELNGNQLMEKRETEGKDSKRNYYSRGHRSIPGVAIDGENNMRQSPQTVFSLPANCDWKPRWLRATWGSSTEHENRGSPPKGNLKGQFRKGTVRTLPPSQGDSQSLDIPNTADSLGGLSFEPGLVRTCNNPVCPPNHVVSLTNNLIGRRVPTDLQI
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Molecular Weight
58.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GJA9, also known as Gap Junction Protein Alpha 9, is a member of the connexin family, playing a crucial role in cell communication by forming gap junctions between adjacent cells. Research into GJA9 has garnered attention due to its potential implications in various physiological and pathological processes. Understanding the structure and function of GJA9 is essential for exploring its involvement in developmental processes, tissue homeostasis, and the pathogenesis of specific diseases. Notably, abnormalities in gap junction intercellular communication have been linked to conditions such as cancer, cardiac disorders, and neurodegenerative diseases. Recent studies have focused on the recombinant expression of GJA9 to facilitate functional assays and investigate its role in cell proliferation, differentiation, and apoptosis. By utilizing recombinant protein techniques, researchers aim to elucidate the functional mechanisms of GJA9 at a molecular level, paving the way for potential therapeutic targets that could modulate gap junction communication in disease contexts. The exploration of GJA9 as a biomarker or therapeutic candidate is increasingly relevant, as advancements in biotechnology allow for the development of novel strategies to manipulate cell signaling pathways, thereby addressing critical challenges in regenerative medicine and disease treatment.
