Analytical Data
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Gene name
GIMAP4
- Application
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Alternative Names
FLJ11110; GIMA4_HUMAN; Gimap4; GTPase IMAP family member 4 ; GTPase IMAP family member 4; hIAN1; HIMAP4 ; Human immune associated nucleotide 1; IAN-1; IAN1 ; IMAP4 ; Immunity associated nucleotide 1 protein; Immunity associated protein 4; Immunity-associated nucleotide 1 protein; Immunity-associated protein 4; MSTP062
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NUV9
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Expression Region
1-329aa
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AA Sequence
MAAQYGSMSFNPSTPGASYGPGRQEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELVVVDTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEVESKDGILELIMTALQIASFILLRLFAED
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Molecular Weight
63.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GIMAP4 (GTPase of immunity-associated protein 4) is a member of the GIMAP family of proteins, which are primarily associated with immune regulation and lymphocyte development. The protein is encoded by a gene located within a region of the human genome that has been linked to autoimmune diseases, such as systemic lupus erythematosus and multiple sclerosis. Initial studies suggested that GIMAP4 plays a critical role in the survival and apoptosis of T cells, indicating its potential influence on immune responses. Research into the recombinant form of GIMAP4 has been driven by the need to understand its precise function and mechanisms at the molecular level. By producing and studying recombinant GIMAP4, researchers aim to elucidate its structural properties, interactions with other proteins, and its role in cellular signaling pathways. This understanding is crucial not only for fundamental immunological research but also for developing therapeutic strategies for autoimmune disorders where GIMAP4 may be implicated. Furthermore, the study of GIMAP4 offers insights into the broader context of immune system regulation and the potential for targeted interventions in immune-mediated conditions. As such, GIMAP4 has garnered attention both as a biomarker for certain diseases and as a potential therapeutic target, making its recombinant protein an important subject of investigation in immunology and related fields.
