Analytical Data
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Gene name
GALNTL5
- Application
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Alternative Names
GALNTL5; GALNT15Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; Polypeptide GalNAc transferase 15; GalNAc-T15; pp-GaNTase 15; Protein-UDP acetylgalactosaminyltransferase 15; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z4T8
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Expression Region
1-443aa
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AA Sequence
MRNAIIQGLFYGSLTFGIWTALLFIYLHHNHVSSWQKKSQEPLSAWSPGKKVHQQIIYGSEQIPKPHVIVKRTDEDKAKSMLGTDFNHTNPELHKELLKYGFNVIISRSLGIEREVPDTRSKMRLQKHYPARLPTASIVICFYNEECNALFQTMSSVTNLTPHYFLEEIILVDDMSKVDDLKEKLDYHLETFRGKVKIIRNKKREGLIRARLIGASHASGDVLVFLDSHCEVNRVWLEPLLHAIAKDPKMVVCPLIDVIDDRTLEYKPSPLVRGTFDWNLQFKWDNVFSYEMDGPEGSTKPIRSPAMSGGIFAIRRHYFNEIGQYDKDMDFWGRENLELSLRIWMCGGQLFIIPCSRVGHISKKQTGKPSTIISAMTHNYLRLVHVWLDEYKEQFFLRKPGLKYVTYGNIRERVELRKRLGCKSFQWYLDNVFPELEASVNSL
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Molecular Weight
77.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GALNTL5, a member of the polypeptide N-acetylgalactosaminyltransferase (GALNT) family, plays a crucial role in O-glycosylation, a post-translational modification essential for various biological processes. O-glycosylation is involved in protein stability, cellular signaling, and interactions between cells and their environments. Research into GALNTL5 has gained attention due to its potential implications in cancer biology, as altered glycosylation patterns can contribute to tumor progression and metastasis. Increased expression of GALNTL5 has been linked to certain malignancies, indicating that it may serve as a biomarker for cancer diagnosis and prognosis. Moreover, understanding the enzymatic mechanisms by which GALNTL5 modifies glycoproteins could reveal novel therapeutic targets for treating diseases characterized by aberrant glycosylation. The recombinant production of GALNTL5 enables a detailed investigation of its enzymatic activity and substrate specificity, offering insights into its biological functions and potential applications in biotechnology and medicine. As researchers continue to explore the structure-function relationships of GALNTL5, the discovery of small molecules or modulators to manipulate its activity could pave the way for innovative treatments targeting glycosylation-related disorders. Thus, GALNTL5 represents a significant focus within glycobiology, linking glycosylation to critical physiological and pathological processes.
