Analytical Data
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基因名
SMN2
- Application
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别名
SMN2；SMN；SMNT；SMN2；Survival motor neuron Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16637
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表达区间
2-294aa
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氨基酸序列
AMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA IWSEDGCIYP ATIASIDFKR ETCVVVYTGY GNREEQNLSD LLSPICEVAN NIEQNAQENE NESQVSTDES ENSRSPGNKS DNIKPKSAPW NSFLPPPPPM PGPRLGPGKP GLKFNGPPPP PPPPPPHLLS CWLPPFPSGP PIIPPPPPIC PDSLDDADAL GSMLISWYMS GYHTGYYMGF RQNQKEGRCS HSLN
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The SMN2 gene, a vertebrate homologue of the survival motor neuron (SMN) gene essential for motor neuron development, plays a critical role in the pathogenesis of spinal muscular atrophy (SMA), a severe genetic disorder characterized by the degeneration of motor neurons leading to muscle atrophy and weakness. The SMN2 gene produces a partial functional protein that is insufficient to prevent SMA due to alternative splicing, leading to the retention of intron 7, which results in the production of a truncated protein. Researchers have been focusing on the development of SMN2 recombinant proteins to better understand SMN function and to explore potential therapeutic strategies. These recombinant proteins are valuable tools for elucidating the molecular mechanisms underlying SMA and may aid in the identification of small molecules or compounds that enhance SMN2 expression or function. Recent advancements in gene therapy and drug development have brought renewed interest in targeting SMN2, making the study of its recombinant protein crucial for developing effective treatments for SMA. Through these efforts, there is hope for improving the quality of life for affected individuals and finding a cure for this debilitating condition.
