Analytical Data
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基因名
PCDH15
- Application
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别名
PCDH15；USH1F；Protocadherin-15
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96QU1
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCDH15 (Protocadherin 15) is a member of the cadherin superfamily and plays a critical role in the development and function of the auditory system and hair cells in the inner ear. Mutations in the PCDH15 gene are associated with various forms of hereditary hearing loss, highlighting its importance in sensory biology. The protein is involved in cell-cell adhesion processes essential for establishing and maintaining the structure of hair bundles in sensory cells. Given the significance of PCDH15 in auditory function, the study of its recombinant protein offers valuable insights into the molecular mechanisms underlying hair cell differentiation and the regulation of mechanotransduction pathways. Additionally, purifying and characterizing PCDH15 can aid in understanding its interactions with other proteins and its role in auditory synapses. Research on PCDH15 recombinant proteins could also pave the way for potential therapeutic approaches to address hearing impairments, as it allows for the exploration of structure-function relationships and the development of strategies to modulate its activity. Overall, the investigation of PCDH15 recombinant proteins is an important area in the field of auditory biology and gene therapy.
